Changes in nuclear factor ?B activity in peripheral blood mononuclear cell in newly diagnosed type 2 diabetes.
- VernacularTitle:新发2型糖尿病患者外周血单核细胞中核因子?B的活性变化
- Author:
Xiulin SHI
;
Feng LI
;
Fangping LI
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes;
NF-?B;
CRP
- From:
Chinese Journal of Practical Internal Medicine
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of nuclear factor?B activity in peripheral blood mononuclear cell(PMNC)in newly diagnosed type 2 diabetic patients.Methods Thirty normal individuals and 30 newly diagnosed type 2 diabetics were selected.Phosphorylation status of NF-?B P65 of PMNC was determined by immunoblotting with phosphor-specific antibodies to NF-?B P65(Ser 536 ).Serum hs-CRP was assayed by enzyme linked immunosorbent assay(ELISA).Results The level of NF-?B P65 phosphorylation was increased in newly diagnosed type 2 diabetic patients compared with control subjects[0.85(0.49,1.02)vs 0.47(0.26,0.67),P
