Long-term survival of hypoxia radiotherapy for carcinoma of uterine cervix
- VernacularTitle:低氧放疗对子宫颈癌的远期疗效
- Author:
Yongheng AN
;
Aiping DING
;
Xiguo CHENG
;
Qingjun SHANG
- Publication Type:Journal Article
- Keywords:
Cervical neoplasms/radiotherapy;
Hypoxia;
Prognosis
- From:
Chinese Journal of Radiation Oncology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between long-term survival rate and protection to marrow and lymphoid tissues in the pelvis with hypoxia radiotherapy for uterine cervical carcinoma. Methods 113 patients, confirmed as having carcinoma of uterine cervix by pathology, were randomly divided by the envelope method into two groups: hypoxia radiotherapy group(HRG,57 patients) and conventional radiotherapy group (CRG,56 patients). HRG was given by sustained inhaling hypoxia gas (oxygen physical volume=0.105) for two minutes before the start of radiotherapy till the end of radiotherapy of each field and then repeated for the other field in the same way. The duration of irradiation to each field was less than five minutes. CRG was given with conventional radiotherapy. The irradiation dose in the midpelvical plane was 20-50Gy depending on the different stages of cervical carcinomatous lesion. The dose of four-divided-field in the parametria was 15-34Gy.The dose at point A of intracavitary therapy was 15-35Gy. Results The decreased value of peripheral blood white cells after treatment was (1.36?1.27)?109/L in HRG and (2.97?1.19)?109/L in CRG(P
