Androgen receptor expression in vibrissa follicle stem cells of rat
- VernacularTitle:雄激素受体在大鼠触须毛囊干细胞中的表达研究
- Author:
Yuanbin LI
- Publication Type:Journal Article
- Keywords:
androgen receptor;
hair follicle stem cells;
hair follicle cycle;
differentiation
- From:Journal of Third Military Medical University
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of androgen receptor(AR) of rat vibrissa follicle stem cells in culture and vibrissa follicle stem cells in vivo at three different phases of a hair follicle cycle,including anagen,catagen and telogen.Methods AR was detected using immunohistochemistry.The expression of AR mRNA was examined by total RNA extraction and RT-PCR.Results In vivo the vibrissa follicle stem cells expressed AR in the whole hair follicle cycle.AR mRNA was strongly expressed in anagen,weakly in catagen and telogen.AR expressed in the cultured vibrissa follicle stem cells.Conclusion The expression of AR mRNA was altered regularly in rat vibrissa follicle stem cells in vivo throughout the hair follicle cycle,which suggested that the interaction between androgen and AR may facilitate the differentiation of vibrissa follicle stem cells.
