Effect of adenovirus-mediated CTLA4Ig on excretive function of submandibular gland in Sjogren syndrome mice
- VernacularTitle:腺病毒介导CTLA4Ig对舍格伦综合征小鼠涎腺分泌功能的影响
- Author:
Long MA
;
Jun YANG
;
Wenjin SHI
;
Yanchun YANG
- Publication Type:Journal Article
- Keywords:
Ad-CTLA4Ig;
Sjogren syndrome
- From:Journal of Third Military Medical University
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the role of adenovirus cytotoxic T lymphocytic associated antigen 4(Ad-CTLA4Ig) in treatment of induced Sjogren syndrome(SS) in mice.Methods SS was induced in 30 BALB/c mice by challenging with the mixture of homologous antigen from submandibular gland tissues and complete freunds adjuvant(CFA).Two hours after challenge,Ad-CTLA4Ig was intraperitoneally injected in the experimental mice(n=10),while thymic peptide in control mice(n=10).Morphological changes of submandibular gland,water intake and static total saliva flow rate of each group were observed.Results There was no obvious pathological change in Ad-CTLA4Ig treated group,in which the static total saliva flow rate was significantly higher than that in control groups(P
