Hypoxia-Inducible Factor-1 and Cerebral Ischemic Tolerance
- VernacularTitle:缺氧诱导因子-1与脑缺血耐受
- Author:
Ruijian DONG
;
Renliang ZHAO
- Publication Type:Journal Article
- Keywords:
hypoxia-inducible factor-1;
cerebral ischemic tolerance;
nuclear protein
- From:
International Journal of Cerebrovascular Diseases
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia inducible factor 1 (HIF-1), a nuclear protein with transcription activity, can make the body produce adaptive response to hypoxia/ischemia by binding to target gene, transcription and post-transcriptional control. Ischemic tolerance refers to the adaptive response to transient ischemia and reperfusion, which can improve tissue tolerance during the following damage caused by more severe ischemic events. The recent studies have found that the expression of HIF-1 has an important significance in ischemic tolerance. HIF-1 may be a key factor of the oxygen signal transduction pathway in the development of cerebral ischemic tolerance.
