Primary study on the relationship between pain of prostatic and activation of glia cells in spinal cord
- VernacularTitle:前列腺炎性疼痛与脊髓胶质细胞活化关系的初步研究
- Author:
Zhansong ZHOU
;
Bo SONG
;
Gensheng LU
- Publication Type:Journal Article
- Keywords:
prostatitis;
pain;
spinal cord;
glia
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between pain of prostatitis and activation of glia cells in spinal cord. Methods To investigate the activation of astroglia cells and microglia cells in spinal cord after irritation of the prostate of the rats with complete Freund′s adjuvant (CFA) at different time using immunohistochemical staining. Results Activation of astroglia cells and microglia cells were significantly increased in deeper laminae and superficial laminae of the dorsal horn of L_6-S_1 spinal cord on the third day, tenth day and twenty-eighth day after CFA irritation of the prostate, and the most obvious activation occurred on the tenth day. Conclusions Activation of glia cells in spinal cord may play an important role in the neuropathological process of the pain of prostatic inflammation. The molecular mechanisms should be further explored.
