Studies on the therapeutic effects and mechanisms of intensive insulin therapy on the stress hyperglycemia caused by severe peritoneal infection
- VernacularTitle:胰岛素强化治疗对腹腔严重感染应激性高血糖的疗效及机制研究
- Author:
Jundong DU
;
Zhanliang LI
;
Jiye LI
- Publication Type:Journal Article
- Keywords:
sepsis;
insulin;
monosaccharide transport proteins;
muscle, skeletal
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect and mechanism of intensive insulin therapy on stress hyperglycemia in rabbits with sepsis. Methods Rabbits were subjected to cecal ligation plus puncture (CLP) to reproduce sepsis. Sixty rabbits were randomly divided into three groups, control group (n=12), CLP group, and intensive insulin therapy group (n=24). The following parameters were measured with the method indicated in parentheses: blood glucose (blood sugar meter), glucose transporter 4 (GluT4) mRNA expression (RT-PCR), GluT4 protein level (Western blot). Results Compare with the control group, the level of blood glucose was significantly increased at 2h after CLP and reached its peak 12h after CLP (P
