The effect of propofol on c-fos gene expression during global myocardial ischemia-reperfusion in isolated rat heart
- VernacularTitle:异丙酚对大鼠离体心脏缺血/再灌注损伤时心肌c-fos基因表达的影响
- Author:
Jin ZHOU
;
Tiezheng ZHANG
;
Fengxue WANG
- Publication Type:Journal Article
- Keywords:
myocardial ischemia;
reperfusion injury;
gene, fos
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effects of propofol on isolated rat heart during global myocardial ischemia-reperfusion. Methods 36 Wistar rats were randomly divided into control group and propofol group. Each group was subdivided into 3 subgroups: preischemia, ischemia 30 minutes and ischemia-reperfusion 30 minutes group. The changes in c-fos protein and c-fos mRNA level in isolated Langendorff perfused rat myocardium were assessed by immunohistochemical technique and RT-PCR technique respectively. Results Compared to preischemia subgroup the expression of c-fos protein and c-fos mRNA level in ischemia 30 minutes and ischemia-reperfusion 30 minutes subgroups were higher significantly (P
