The effect of the ischemic preconditioning on intestinal mucosal barrier after pancreas transplantation in rat
- VernacularTitle:缺血预处理对胰腺移植受鼠小肠黏膜屏障的影响
- Author:
Xiaonan LIU
- Publication Type:Journal Article
- Keywords:
Pancreas transplantation;
Ischemic preconditioning;
Intestinal mucous barrier;
Rat
- From:
Parenteral & Enteral Nutrition
1997;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the protective effect of the ischemic preconditioning on intestinal mucosal barrier after the rats' pancreas transplantation and analyze the possible mechanism.Methods:Group control included 12 normal rats received sham operation,36 steptozozin-induced diabetic SD rats were randomly assigned to 3 groups: Group I/R consisted of 12 diabetic rats which received pancreas transplantation alone,Group DIPC consisted of 12 diabetic rats which received pancreas transplantation with ischemic reperfusion in the pancreas graft before ablating donors,Group DIPC consisted of 12 diabetic rats which received pancreas transplantation with ischemic reperfusion in the recipient.The intestinal permeability,absorptional function and morphology,the TNF-?,NO,SOD and amylase activity in serum,MDA,SOD and MPO in intsetinal tissue were monitored 5 day after reperfusion.Simultaneitily,the bacteria translocational ratio of mesentery lymph node,liver and spleen were observed.Results:The TNF-? level,the amylase activity in serum(P0.05),the degree of intestinal mucous injury,the apoptosis index(P
