Study of peripheral and central mechanism of visceral hypersensitivity in non-erosive reflux disease patients
- VernacularTitle:非糜烂性反流病内脏高敏感的外周与中枢机制研究
- Author:
Xiaorong XU
;
Zhaoshen LI
;
Min YANG
- Publication Type:Journal Article
- Keywords:
Gastroesophageal reflux;
Non-erosive reflux disease(NERD);
Visceral hypersensitivity;
Cerebral evoked potentials(CEP);
Calcitonin gene related peptide(CGRP);
Substance P(SP)
- From:
Chinese Journal of Practical Internal Medicine
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this study was to evaluate and to characterize the visceral hypersensitivity in non-erosive reflux disease(NERD)through the detection of esophageal distension-cerebral evoked potentials(ED-CEP)and calcitonin gene related peptide(CGRP)and substance P(SP)levels in esophageal mucosa.Methods NERD patients(N 26)and 12 controls were enrolled in this study from Oct.2004 to Mar.2005.Mechanical distention stimulation was performed using the balloon-affixed and polyvinyl multilumen catheter.The ED- CEP was recorded with a muti-channel international 10~20 system of electroencephalograph.The esophageal specimens were immune-histologically evaluated for CGRP/SP-stain positive contents.Results Esophageal distention may evoke recognizable and reproducible muti-peak CEP.CEP morphology of NERD patients was characterized by randomly distributed patterns,and the peak latencies for N1,P1,and N2 were significantly shorter compared with control group(P
