Relationship between substance P and histamine release of mast cells in human hypertrophic scar
- VernacularTitle:P物质对增生性瘢痕中肥大细胞组胺释放的影响
- Author:
Liang CHEN
;
Shirong LI
;
Lin CONG
- Publication Type:Journal Article
- Keywords:
hypertrophic scar;
substance P;
mast cell;
histamine release
- From:Journal of Third Military Medical University
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect a quantitative relation between reaction time of substance P (SP) and histamine release of mast cells (MC) in hypertrophic scar (HS) and discuss the interaction and time-effect of substance P and histamine release in HS. Methods The HS specimens were from the 4 to 7-year-old scalded or burnt patients who underwent operation because of cicatricial contraction. The normal skins were the autograft. HS specimens were cut into 0.5-1 mm 3, then treated with 5?10 -5 mol/L SP for 5, 15, 30, 60 min. The degranulation of MC was detected and the histamine released by mast cells in the supernate after SP treatment was examined by immunofluorescence. Conclusion SP and MC are of a close relationship in HS, and SP can affect histamine release of mast cell in time-dependent manner.
