EFFECTS OF ACUTE HYPOXIA AT DIFFERENT SIMULATED HIGH ALTITUDE ON THE APPEPTITE AND EXPRESSION OF NEUROPEPTIDE Y IN HYPOTHALAMUS OF RATS
- VernacularTitle:高原急性低氧对大鼠食欲及下丘脑神经肽Y表达的影响
- Author:
Xiuling TIAN
;
Mantian MI
- Publication Type:Journal Article
- Keywords:
acute hypoxia;
appetite;
hypothalamus;
neuropeptide Y;
immunohistochemistry
- From:
Acta Nutrimenta Sinica
1956;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the effect of acute hypoxia on the appetite and expression of neuropeptide Y (NPY) in rat hypothalamus. Methods: Wistar rats were randomly divided into control group, 3 000 m group, 4 000 m group , 5 000 m group and 6 000 m group for different times (1d, 2d and 3d respectively) . The change of appetite was observed and the expression of NPY in hypothalamus of rats was measured by immunohistochemical method. Results: (1) After acute hypoxia, the appetite of rats decreased. (2) The expression of NPY of the test groups and the normal group was decreased in arcuatus, paraventricular and dorsal median nucleus of the hypothalamus after acute hypoxia. Conclusion: Acute hypoxia might inhibit feed intake of rats, and decreased expression of NPY in hypothalamus, which may be one of the important reasons for loss of appetite.
