EFFECTS OF AGAR-OLIGOSACCHARIDES ON BLOOD GLUCOSE LEVEL AND OXIDATION-ANTIOXIDATION STATUS OF DIABETIC MICE
- VernacularTitle:琼脂寡糖对糖尿病小鼠血糖和氧化-抗氧化态的效应
- Author:
Haimin CHEN
;
Xiaojun YAN
- Publication Type:Journal Article
- Keywords:
agaro-oligosaccharides;
agarobiose;
blood glucose level;
diabetes;
antioxidation
- From:
Acta Nutrimenta Sinica
1956;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of agar-oliogsaccharides (mainly containing agarobiose) on blood glucose level and oxidation-antioxidation status in alloxan-induced diabetic mice. Method: The inhibitory activity of agarobiose on ?-glucosidase was investigated. Alloxan was used to establish non-obese diabetic (NOD) mice model. After 14 d administration of agarobiose, blood glucose, MDA, SOD, GSH and GSH-Px levels were determined. Results:Agarobiose showed inhibitory activity on ?-glucosidase with IC50=1.39 mg/ml, Ki=0.52 mg/ml. In a certain concentration (200-400 mg/kg bw), agaro-oligosaccha- rides reduced the blood glucose level remarkably, and the oxidative indices were also improved in heart, liver, lung and brain. The blood glucose level (P
