Neuronal nicotinic acetylcholine receptor-mediated Ca~(2+) signals and regulation
- VernacularTitle:神经元烟碱受体介导的钙信号及其调节作用
- Author:
Jun HU
;
Gang HU
;
Jie WU
- Publication Type:Journal Article
- Keywords:
neuronal nicotinic acetylcholine receptor;
Ca~(2+) permeability;
signal transduction;
neuroprotection
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
1999;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Neuronal nicotinic acetylcholine receptors(nAChRs) are widely distributed in the central nervous system,and they participate in complex neuronal signal transduction and regulation in the brain.The high Ca~(2+) permeability of nAChRs,plays a pivotal role in shaping nAChRs-induced neuromodulatory effects.The nAChRs-mediated Ca~(2+) signals may regulate diverse neuronal activities such as the improvement of learning and memory,and are closely related to drug addiction or neuroprotection mechanism.
