Protective effects of penehyclidine hydrochloride on transient forebrain ischemia reperfusion injury in gerbils
- VernacularTitle:盐酸戊乙奎醚对沙土鼠前脑缺血再灌注损伤的保护作用
- Author:
Tengfei MA
;
Rong JIN
;
Jing ZHANG
;
Shuling GU
;
Shiming DUAN
- Publication Type:Journal Article
- Keywords:
cerebral ischemia;
gerbils;
muscarinic receptors;
superoxide dismutase;
malondialdehyde
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
1999;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To study the protective effects of penehyclidine hydrochloride(PHC) on transient forebrain ischemia reperfusion injury in gerbils.METHODS:The model of transient forebrain ischemia reperfusion was established in gerbils by bilateral carotid artery clamping.The effects of PHC on neurological function scores and the morphous of hippocampal pyramidal neuron of gerbils were observed after receiving transient forebrain ischemia reperfusion.SOD activities and contents of MDA in the hippocampus and cortex of gerbils were measured.RESULTS:In the groups of PHC(0.08),(0.24)(mg?kg~(-1)) and atropine,the stroke index was decreased,compared with the ischemia-reperfusion group after the gerbils received transient forebrain ischemia reperfusion for six hours.PHC could reduce the degree of injury in hippocampal pyramidal neuron after ischemia reperfusion for three days.CONCLUSION: PHC has protective effects on transient forebrain ischemia reperfusion injury in gerbils.
