Change of decreasing blood pressure on pain threshold of spontaneously hypertensive rats
- VernacularTitle:自发性高血压大鼠降压前后的痛阈改变
- Author:
Xiaoyu LIU
;
Dangfang WU
;
Yan ZHOU
;
Jie LI
;
Yanhai ZHANG
- Publication Type:Journal Article
- Keywords:
blood pressure;
pain threshold;
paw withdrawal mechanical threshold;
paw withdrawal thermal latency
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
1999;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of decreasing blood pressure on mechanical and heat pain sensitivity in spontaneously hypertensive rats.METHODS: 15 SHRs were intramuscularly given reserpine(1(?g?kg~(-1)?d~(-1))) on day 4-11.Blood pressure,paw withdrawal mechanical threshold(PWMT) and paw withdrawal thermal latency(PWTL) were measured every day.RESULTS: After the therapy of reserpine in spontaneously hypertensive rats,blood pressure decreased by 50 mmHg,mechanical and heat pain threshold were both decreased(P
