Peroxisome prolifreator-activated receptors and neurodegenerative diseases
- VernacularTitle:PPARs与神经退行性疾病
- Author:
Huiling ZHANG
;
Zhenlun GU
;
Zhenghong QIN
- Publication Type:Journal Article
- Keywords:
PPARs;
neurodegenerative diseases;
nuclear hormone receptors;
cerebral ischemia;
neuroprotection
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Peroxisome prolifreator-activated receptors (PPARs) are ligand-activated nuclear transcription factors, members of nuclear hormone receptor superfamily. PPARs play critical roles in growth, proliferation and apoptosis of variety of cells. Recently, PPAR ligands have been reported to ameliorate neuronal damage in neurodegenerative diseases including Alzheim- ers disease, Parkinsons disease,cerebral ischemia and multiple sclerosis. PPAR agonists may have potential values in treatment of neurodegenerative diseases. In this paper, we reviewed recent findings on PPARs′ neuroprotective actions and their underlying mechanisms.
