Characteristics of peripheral circulating lymphocyte subsets and their clinical implication in severe hepatitis patients with chronic HBV infection
- VernacularTitle:慢性乙型重型肝炎患者外周血各亚群淋巴细胞绝对值的特点
- Author:
Shaojie XIN
- Publication Type:Journal Article
- Keywords:
hepatitis B,chronic;
lymphocytes;
prognosis
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the characteristics of peripheral circulating lymphocyte subsets in severe hepatitis patients with chronic HBV infection(SHPCHI).Methods: The numbers of circulating lymphocyte subsets,including CD3~(+),CD4~(+) and CD8~(+),NK cells(CD3~(-)/CD16~(+)/CD56~(+)),and NKT cells(CD3~(+)/CD16~(+)CD56~(+)),were determined in SHPCHI((n=61),)patients with chronic hepatitis B(CHB,n=21),patients with cirrhosis(LC,n=26) and healthy volunteers(n=10) by flow cytometry.The absolute values of each lymphocyte subset were calculated and statistically analyzed.Results: The absolute numbers of circulating CD3~(+),CD4~(+)and CD8~(+) T cells were significantly reduced in SHPCHI group compared with those in the other 3 groups(P
