Helicobacter pylori genotypes of gastrointestinal B cell lymphoma
- VernacularTitle:胃肠B细胞淋巴瘤中幽门螺杆菌的基因表型
- Author:
Hongfang YIN
;
Ting LI
- Publication Type:Journal Article
- Keywords:
Gastrointestinal neoplasms;
Lymphoma, B-cell;
Helicobacter pylori;
Genotype
- From:
Journal of Peking University(Health Sciences)
2004;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the expression of specific virulence-associated Helicobacter pylori (Hp) genotypes, (cag A, vac A, and ice A status) in primary gastrointestinal B cell lymphoma. Methods: Forty-nine paraffin wax embedded tissues were analyzed by immunohistochemical staining and poly-merase chain reaction. Results:There were 14 cases of mucosa associated lymphoid tissue lymphoma ( MALT-L) (8 in stomach, and 6 in intestine) and 35 cases of diffuse large B cell lymphoma (DLBCL) (21 in stomach, and 14 in intestine) in all. The positive rates of vac A s1 ,vac A s2 ,vac A m2,ice A 1 and cag A were 50. 0% ,42. 9% ,50. 0% , 14. 3% and 85. 7% in MALT-L; 57. 1% ,40. 0% ,25. 7% , 5.7% and91.4% in DLBCL, respectively. Conclusion:High toxicity cag A + Hp strains.seem to play a role in the pathogenesis of gastrointestinal B cell lymphoma, whereas vac A m2 may be more associated with MALT-L. Clinical stage was not associated with virulence-associated Hp genotypes.
