Effect of esophageal mucosal acid exposure on visceral sensation of patients with non-erosive gastroesophageal reflux disease
- VernacularTitle:食管酸灌注对非糜烂性胃食管反流病患者食管内脏敏感性的影响
- Author:
Min YANG
;
Dianchun FANG
;
Zhaoshen LI
;
Xiaorong XU
;
Duowu ZOU
;
Zhenxing SUN
;
Zhenxing TU
;
Guoming XU
;
Yanfan GONG
- Publication Type:Journal Article
- Keywords:
non-erosive gastroesophageal reflux disease;
esophageal cortical evoked potentials;
esophageal acid perfusion;
visceral hypersensitivity
- From:Journal of Third Military Medical University
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of esophageal mucosal acid exposure on visceral sensation of patients with non-erosive gastroesophageal reflux disease (NERD) and to evaluate the role of visceral hypersensitivity in NERD pathogenesis. Methods We recruited 21 NERD patients and 10 normal healthy volunteers. Mechanical distentions stimulation and acid perfusion through esophagus were performed using the balloon-affixed and polyvinyl multilumen catheter. Esophageal visceral perception thresholds were examined before and after acid perfusion with esophageal balloon distention by means of a computer-controlled barostat. Results As compared with healthy subjects, NERD patients demonstrated significantly lower initial perception threshold and maximally tolerated pain threshold (P
