The study on the association between ?_2-adrenoceptor genetic single nucleotide polymorphisms and atrial fibrillation
- VernacularTitle:?_2-肾上腺素能受体单核苷酸多态性与心房颤动的相关性研究
- Author:
Ping ZHANG
;
Jihong GUO
;
Shumin WANG
- Publication Type:Journal Article
- Keywords:
Atrial fibrillation;
?_2-adrenoceptor gene;
Single nucleotide polymorphism
- From:
Chinese Journal of Practical Internal Medicine
2002;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine whether the ?_2-adrenoceptor genetic single nucleotide polymorphisms are associated with atrial fibrillation.Methods A case-control study was performed on 218 subjects,including 58 subjects with lone atrial fibrillation,50 subjects with atrial fibrillation and essential hypertension,50 subjects with essential hypertension and 60 healthy controls.The ?_2-adrenoceptor polymorphisms at amino acids 16 and 27 were identified by allele specific polymerase chain reaction(PCR).Results The Gly/Gly genotype as well as the Gly16 allele at amino acids 16 was significantly more common in the atrial fibrillation group than in the non-atrial fibrillation group.But there was no significant differenece in the allele frequency or the genotype frequency of the Gln27 Glu polymorphism between the two groups.In addition,the difference in the distribution of polymorphisms at amino acids 16 and 27 between the four different observed groups was not significant either.Conclusion Gly16 polymorphism of the ?_2-adrenoceptor overrepresenting in the atrial fibrillation group seems to be associated with atrial fibrillation.
