Expression of extracellular signal-regulated kinase in liver fibrotic tissues of human
- VernacularTitle:人纤维化肝组织中胞外信号调节激酶的表达
- Author:
Bing NONG
;
Zengwen LIANG
;
Qingnan ZHOU
- Publication Type:Journal Article
- Keywords:
Liver fibrosis;
Extracellular signal-regulated kinases
- From:
Chinese Journal of Practical Internal Medicine
2002;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of Extracellular signal-regulated kinase(ERK)signal transduction pathway in the mechanism of liver fibrosis via investigating the expression of ERK1 in fibrotic liver tissue of human.Methods SABC immunohistochemistry was used to detect the expression of ERK1 in 32 liver fibrosis and 12 normal liver tissues from Jan.2001 to Dec.2003.Results The expression of ERK1 in liver fibrotic tissues were found chiefly in hepatic stellate cells(HSC),and it presented with significantly progressive tendency for the expression of ERK1 in normal and liver fibrosis cirrhosis tissues(P
