Effect of exogenous nitric oxide on Schistosoma japonicum in mice
- VernacularTitle:外源性一氧化氮抗日本血吸虫的实验研究
- Author:
Yanrui WANG
;
Xinsheng ZHENG
;
Baoan YAO
;
Cunzheng DUAN
- Publication Type:Journal Article
- Keywords:
Exogenous nitric oxide;
Emulsion;
Schistosoma japonicum
- From:
Chinese Journal of Schistosomiasis Control
1989;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of exogenous nitric oxide (NO) on Schistosoma japonicum in mice. Methods The emulsion of nitric oxide was performed by the reversal emulsifying method and beeswax was used as an agent absorbing NO. Each mice on the day 22 post-infection with cercariae was orally administracted with exogenous NO emulsion 0.5 ml once a day for five days. The worms of Schistosoma japonicum were collected by perfusion and counted to observe the effect of exogenous NO on Schistosoma japonicum. Results The concentration of exogenous NO was 536.2 ?mol/L. Exogenous NO could reach certain therapy efficacy with the worm reduction rate of 45.0% and the egg reduction rate of 42.7%. Conclusion Exogenous NO may be considered as a novel medicament of schistosomiasis japonica.
