P-Glycoprotein and Blood-Brain Barrier
- VernacularTitle:P-糖蛋白与血脑屏障
- Author:
Xuehong JIN
;
Shiyao BAO
- Publication Type:Journal Article
- Keywords:
P-glycoprotein;
blood-brain barrier;
multidrug resistance;
P-glycoprotein inhibitors
- From:
International Journal of Cerebrovascular Diseases
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
P-glycoprotein is one of the members in the superfamily of ATP-binding cassette transporters. It is expressed in many sites in vivo, and is correlated with multidrug resistance. Under physiological conditions, as an efflux pump, P-glycoprotein in the blood-brain barrier can eliminate endogenous substrates and xenobiotics to maintain the balance of internal environment. But at the same time, it also limits the concentration of therapeutic drugs in brain, and thus reduces therapeutic efficacy. P-glycoprotein inhibitors can get drugs across the blood-brain barrier. It is of great importance to improve the blood concentration in brain and bioavailability of central nervous system drugs.
