The Effect of Lysophosphatidic Acid on the Permeability of Blood-Brain Barrier
- VernacularTitle:溶血磷脂酸对血脑屏障通透性的影响
- Author:
Ying YU
;
Zhaohui ZHANG
- Publication Type:Journal Article
- Keywords:
lysophosphatidic acid;
blood-brain barrier;
endothelial cell;
astrocyte
- From:
International Journal of Cerebrovascular Diseases
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Lysophosphatidic acid is a intermediary metabolite in lipid metabolism, mainly produced from activated platelets. It may cause the apoptosis of hippocampal neurons, abnormal phosphorylation of tau protein and increased permeability of the tight junction of endothelial cells, which is closely correlated with pathological changes of ischemic cerebrovascular diseases, Alzheimer's disease and vascular dementia. It is shown that lysophosphatidic acid may induce the opening of the blood-brain barrier under pathological conditions, and enters central nervous system through the blood-brain barrier, and causes different effects of pathological changes by acting on various cells.
