Sequence analysis of HIV-1 strains from 2 mother-to-child cases
- VernacularTitle:2例人类免疫缺陷病毒Ⅰ型母婴传播病例的毒株序列分析
- Author:
Jing ZHANG
;
Tongzhan WANG
;
Xiangdong YOU
- Publication Type:Journal Article
- Keywords:
HIV-1;
Disease transmission, vertical;
Sequence analysis
- From:
Chinese Journal of Infectious Diseases
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the origin of HIV-1 strains from 2 mother-to-child cases. Method DNA fragments of HIV-1 gag gene were amplified by nested PCR from the 4 target persons, and the amplified region were sequenced. Results The sequence of the specified fragment from all persons were analyzed and the strains were belonged to subtype A/E, while the sequence between mother's and child's is highly homologous. Conclusion 2 children were infected by mother-to-child transmission.
