Serum Pharmacology Research on Vitro Effects of Changantai on Co26lu Colon Cancer cells
- VernacularTitle:中药肠安泰体外对Co26 lu大肠癌细胞的血清药理学研究
- Author:
Wenping WANG
- Publication Type:Journal Article
- Keywords:
Changantai;
serum pharmacology;
colon cancer Co26lu cell strain
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To detect the ability of medicine serum of Changantai and its major components to kill Co26lu colon cancer cells in vitro by means of serum pharmacology.Methods: There were 5 groups of rats.5-Fu 30mg/kg were injected into the abdominal cavity of the rats in 5-Fu blood serum group and abdominal aorta blood was drawn 1 hour after administration.The other four groups were intragastrically administrated with Changantai(dry paste),rhubarb(dry paste),radix actinidiae(dry paste) and NS 0.6ml/kg/d respectively and the blood was draw twice,that was,2ml orbital vein hemospasia 1 hour after administration and abdominal aorta hemospasia 1 hour after the last administration of three consecutive days with asceptic serum segregation.Ability of medicine serum to kill tumor cells was observed by means of MTT method.Results: medicine serum of 5-Fu,Changantai and its components with different concentration had different ability in vitro to kill Co26lu cells,which was concentration dependent.Conclusion: Changantai can inhibit cancer cells from growing and metastasis.
