The establishment of rat glioma model for MRI study
- VernacularTitle:适于MRI研究的脑胶质瘤模型的建立
- Author:
Dong ZHANG
;
Xiaoyuan FENG
;
Xing WU
;
Jianhong ZHU
- Publication Type:Journal Article
- Keywords:
Glioma;
Animal model;
Magnetic resonance imaging
- From:
Chinese Journal of Radiology
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a rat model of glioma for MRI study.Methods Fischer 344 rats were inoculated with F98 glioma cells in caudate nucleus by stereotaxic procedure.MRI scanning and pathology examination were performed to observe the tumor growth on 6,8,10,12,and 14 d, respectively,after inoculation and their survival was also analyzed.Results After inoculation,tumors were found in all rats by MRI as early as 6 days.Most of rats died on 14 d after inoculation.The volume of tumor increased as the inoculation time lengthened.The tumor volume measured by MRI was larger than actual size by autopsy,but the both correlated positively(r=0.91,P
