Analysis of -477C/T single nucleotide polymorphism in promoter region of ATP binding cassette transporter A1 (ABCA1) gene in 96 patients with coronary artery disease accepted percutaneous coronary intervention
- VernacularTitle:96例冠心病介入治疗患者ABCA1基因启动子区-477C/T单核苷酸多态性分析
- Author:
Zhigang GUO
;
Shenglin LIU
;
Yan TU
- Publication Type:Journal Article
- Keywords:
ATP binding cassette transporter A1;
polymorphism, single nucleotide;
genes, ABCA1;
coronary disease;
lipoproteins, HDL
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of -477C/T single nucleotide polymorphism (SNP) in promoter region of ABCA1 gene on plasma levels of high density lipoprotein cholesterol (HDL-C) and coronary artery disease (CAD). Methods -477C/T genotypes in promoter region of ABCA1 gene were assessed in 96 CAD patients and 100 healthy individuals with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and distribution of the -477C/T genotypes was compared between CAD group and healthy group, and also between patients with different CAD clinical manifestations. The clinical indexes associated with CAD were also compared among the three genotypes. Results The distributive frequency of CC, CT, or TT genotype of CAD group and healthy group was different from one another, and the proportion of the TT genotype or the T allele was obviously higher in CAD group than in healthy group (P
