Role of angiotensin Ⅱ receptors in collagen synthesis of fibroblast in human hypertrophic scars
- VernacularTitle:血管紧张素Ⅱ受体在增生性瘢痕成纤维细胞胶原合成中的作用
- Author:
Hongwei LIU
;
Biao CHENG
;
Wenlin YU
- Publication Type:Journal Article
- Keywords:
receptor, angiotensin, type 1;
receptor, angiotensin, type 2;
hypertrophic;
Hypertrophic scars;
fibroblasts;
skin
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression of both type 1 (AT1) and type 2 (AT2) receptors of angiotensin Ⅱ (AngⅡ) in human hypertrophic scars, and to explore theirs role in collagen synthesis of fibroblasts in human hypertrophic scars. Methods The expression of both AT1 and AT2 receptors in fibroblasts of hypertrophic scars was detected with immunohistochemical staining and radioligand receptor binding assay. Collagen synthesis was examined in cultured in vitro fibroblasts of hypertrophic scars by measuring [~3H]proline incorporation into collagenous proteins. Results Positive staining signals of both AT1 and AT2 receptors were found in fibroblasts of hypertrophic scars. Similar results were also got in cultured in vitro fibroblasts of hypertrophic scars, expression level of AT1 and AT2 receptors were 10.69?2.15fmol/10~6cells and 4.9?1.05fmol/10~6cells respectively. In cultured in vitro fibroblasts, AngⅡ may accelerate the collagen synthesis significantly (P
