Expression of E2F-1 and Bcl-2 in Human Colorectal Carcinoma and Their Clinical Significance.
- VernacularTitle:结直肠癌组织中E2F-1、Bcl-2蛋白的表达及其临床意义
- Author:
Liling YUE
;
Guoxin WU
;
Haitao YU
;
Lihong ZHENG
;
Yu WANG
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
E2F-1;
Bcl-2;
Immunohistochemistry
- From:
Journal of Medical Research
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study was designed to investigate the expression and clinical significance of transcription factor E2F-1 and apoptosis-off gene Bcl-2 in human colorectal carcinoma.Methods Immunohistochemistry is used to detect the expression of E2F-1、Bcl-2 proteins in 60 cases of human colorectal carcinoma tissues and their corresponding normal mucosa.Results The positive expression rate of E2F in cancer tissues is 56.7%,while the positive expression rate of E2F in corresponding normal mucosa is 6.7%,so the comparison between two tissues is significant (P
