Study of platelet activation in active ulcerative colitis
- VernacularTitle:血小板激活与活动期发生溃疡性结肠炎的关系
- Author:
Zhiyong HUANG
;
Guoqiong ZENG
;
Xudong TAN
;
Yuanquan LIN
- Publication Type:Journal Article
- Keywords:
Ulcerative colitis;
Platelet activation;
Platelet aggregation;
P-selecin;
Thromboxane B_2
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine whether platelet activation is associated with active ulcerative colius(UC).Methods Platelet aggregability was assessed by means of SH-93 intelligent blood aggregation and coatgulation tester;P-selectin and thromboxane B_2(TXB_2) were detected by means of ELISA method in patients with UC as well as in controls,including healthy volunteers and patients with irritable bowel syndrome(IBS).Colonoscopy and biopsy were performed in 45 patients with UC.Results Increased circulating platelet aggregability was detected in active colitis ulcerative colitis compared with IBS and healthy controls(P
