Effects of resveratrol on isolated coronary artery rings of canine
- VernacularTitle:白藜芦醇对离体犬冠状动脉血管环的影响
- Author:
Liang CHEN
;
Jianhua TANG
;
Huang HUANG
- Publication Type:Journal Article
- Keywords:
resveratrol;
17?-estradiol;
coronary artery;
vascular tension;
endothelium;
voltage-dependent calcium channel
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the relaxative characteristics of resveratrol(RES) and 17?-Estradiol(EST) on coronary arteries in dogs and its mechanism.METHODS: Rings of canine coronary arteries were suspended in organ baths containing Krebs-Henseleit solution,and then isometric tension was measured.RESULTS: Both RES and EST caused the does-response contractile curve of KCl in K-H solution and CaCl_2 in Ca~(2+)-free K-H solution shift rightward,and their sensitivies and the values of maximum contractions had been decreased.In the N?-L-nitro-arginine,Methylene Blue and Sodium Orthovanadate groups,the vasorelaxant effects of both estrogens were markedly attenuated(P(0.05)).CONCLUSION: Resveratrol and 17?-Estradiol relaxe vascular smooth muscle in an endothelium-dependent manner,and are not related to KATP channel.
