Protective effects of adenovirus-mediated gene transfer of soluble complement receptor type 1 on acute myocardium ischemia: an experimental study
- VernacularTitle:腺病毒介导的可溶性Ⅰ型补体受体基因转染对急性心肌缺血的保护作用的实验研究
- Author:
Shengdong HUANG
- Publication Type:Journal Article
- Keywords:
myocardial ischemia;
soluble complement receptor type 1;
adenovirus;
transfection
- From:
Academic Journal of Second Military Medical University
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the protective effects of adenovirus-mediated gene transfer of soluble complement receptor type 1(sCR1) on acute myocardium ischemia in mice.Methods: Twenty-seven SD rats were subjected to left anterior descending coronary artery(LAD) occlusion(30 min) and reperfusion.In the treatment group(n=14),a mixture of adenovirus carrying sCR1 and LacZ was injected into the ischemic zone(100 ?l,10~(10)pfu)5 min before reperfusion;in the control group,only adenovirus carrying LacZ was injected(n=13).Echocardiography was performed 2 weeks later,followed immediately by pathologic examination.Results: Echocardiographic results of the treatment group were better than those of the control group((P
