The synergistic effect of Danshen injection combining with suicide gene tk/GCV system
- VernacularTitle:丹参注射液对自杀基因tk/GCV系统的协同增效作用
- Author:
Yuhui TAN
;
Yingya WU
;
Huifeng WANG
;
Wenling YUE
;
Biaoyan DU
- Publication Type:Journal Article
- Keywords:
Danshen;
suicide gene therapy;
bystander effect;
hepatocarcinoma
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the curative effect of Danshen injection combining with HSV-tk/GCV system on rats′ hepatocarcinoma cells and murine transplanted hepatocarcinoma.Methods ① Rats′ hepatocarcinoma cell line CBRH7919(tk~-),CBRH7919/tk(tk~+) and the 5% tk~+ mixed cells were treated with diverse concentrations of Danshen injection,GCV separately,and Danshen injection plus GCV(n=3).The survival rate of each groups was examined using MTT Assay and was analyzed using paired comparison.Q-value analysis method was used to estimate the synergistic effect of Chinese herbal on the suicide gene system.Q-value is a ratio of the actural effect of combination treatment to its theoretical effect.It is thought to be an additive effect when 0.85≤Q
