Astragalus and Angelica mixture ameliorates renal interstitial fibrosis by a multiple manner
- VernacularTitle:黄芪当归合剂对肾间质纤维化的多靶点抑制作用
- Author:
Liqiang MENG
;
Lei QU
;
Xiaomei LI
- Publication Type:Journal Article
- Keywords:
Astragalus;
Angelica;
fibrosis;
TGF-?_1;
obstructive nephropathy
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim The mixture of Chinese herbs,Astragalus & Angelica(A&A) has been found that has antifibrotic effect in rats.Methods To elucidate themechanisms underlying the renoprotective effects of A&A in the process of renal interstitial fibrosis,we investigated the pathology changes of kidneys in unilateral ureteral obstruction(UUO) rats.In the study,Wistar rats were randomly divided into CON,Sham,UUO and UUA(UUO+A&A) groups.After administration of A&A(12 g?kg?d~(-1)) for 0,3,7 and 10 d,renal damage including interstitial cell infiltration,tubular atrophy and interstitial fibrosis were quantified on HE and Masson stained tissue sections.The expression of ?-smooth muscle actin(?-SMA),transforming growth factor-?_1(TGF-?_1) and fibronectin(FN) was measured using computer image analysis of immunohistochemistry staining sections,ELISA and Western Blot.Results Renal damage and the expression of ?-SMA,TGF-?_1 and FN were all significantly exacerbated in UUO group compared with those of Sham group(P
