The expression and role of ERK and JNK in cerebral ischemic preconditioning in gerbil
- VernacularTitle:ERK和JNK通路在沙土鼠脑缺血预处理中的表达及作用
- Author:
Yaoqi WANG
- Publication Type:Journal Article
- Keywords:
ERK;
JNK;
IP;
cerebral ischemia;
gerbil
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the expression and role of ERK and JNK in cerebral ischemic preconditioning in gerbil.Methods Forebrain ischemia was induced by occlusion of bilateral carotid arteries.Gerbils were randomly divided into sham group(SH),ischemic-preconditioning control group(IC),ischemic-preconditioning group(IP),ischemia-reperfusion group(IR).The gerbils were killed in 15 min,2,4,6 h,1,3,5 and 7 d in each group following reperfusion.Open field test was used to examine the behavioral deficit in the due time.The number of surviving and apoptosis neurons in hippocampal CA1/3 region was counted,and the activity of p-ERK and p-JNK in hippocampus was detected using SP immunocytochemical technique.Results The behavioral mark and the number of apoptosis neurons in hippocampal CA1 region in group IP were much less than that in group IR(P
