The pathologic changes of myocardial fibrosis in diabetes mellitus myocardiopathy
- VernacularTitle:大鼠糖尿病心肌病心肌纤维化病理改变
- Author:
Zinan ZHANG
;
Wei WU
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus myocardiopathy;
Immunohistochemistry;
Transmission electron microscope;
Collagen;
Cardiac-type action;
Transforming growth factor beta1
- From:
Chinese Journal of Practical Internal Medicine
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate pathologic changes of myocardial fibrosis at different stages of diabetes mellitus(DM)rats.Methods (1)Cardiac muscle models of DM rats were divided into groups at random.(2)The hydroxy proline contents were measured with the chloramine T method.The type Ⅰ collagen,type Ⅲ collagen,transforming factor beta1(TGF-beta1)and cardiac-type ?-actin were determined by myocardial immunohistochemical stain.(3)Specimen for light microscope and transmission electron microscope preparation.Results The collagen expression of six-month group was much higher than those of three-month group(P
