Comparison of Hemostasis Mechanisms between Radix Rubiae and Charred Radix Rubiae
- VernacularTitle:茜草饮片炒炭前后止血机制的比较
- Author:
Weihua ZHANG
- Publication Type:Journal Article
- Keywords:
Radix Rubiae;
charred Radix Rubiae;
hemostasis mechanism
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the hemostasis mechanisms of Radix Rubiae and charred Radix Rubiae.Methods: The effects of Radix Rubiae and charred Radix Rubiae were compared in terms of the clotting time,bleeding time,blood platelets count and capillary permeability on mice,and the TT,PT and APTT on pathologicalbleeding models incurred by Heparin and Warfarin and rats.Results: Radix Rubiae and charred Radix Rubiaeall canrestrain the capillary permeability of abdominal cavity in mouse,and obviously shortenthe TT,PT and APTT of rat,but charred Radix Rubiae was more effective than Radix Rubiae.The large and small doses of Radix Rubiae and the large dose of charred Radix Rubiae can elevate the blood platelets count,and obviously antagonize Heparin and Warfarin,and Radix Rubiae was more effective than charred Radix Rubiae.Conclusion: Radix Rubiae has the hemostasis effect through elevating the blood platelets count and antagonizing Heparin and Warfarin,but charred Radix Rubiae through restraining the capillary permeability and shortening the TT,PT and APTT.They have different hemostasis mechanisms.
