Repair effect of hBD_2-modified dermal multipotent stem cells transplantation on infected wound
- VernacularTitle:hBD_2修饰真皮多能干细胞促进感染创面修复的初步实验研究
- Author:
Nan LI
;
Taoyuan XIAO
;
Yongping SU
;
Hui XU
;
Junping WANG
;
Zhaowen ZONG
;
Shiwu DONG
;
Xinze RAN
;
Zhijun LIU
- Publication Type:Journal Article
- Keywords:
human ?-defensin 2;
dermal multipotent stem cells;
wound repair;
infection
- From:Journal of Third Military Medical University
1988;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the repair effect of human ?-defensin 2 (hBD 2)-modified rat dermal multipotent stem cells (dMSCs) transplantation on infected wound. Methods Thirty Wistar rats were excised a piece of whole-layer back skin, 3 mm in diameter, then infected the wound with 1?10 8/ml pseudomonas aeruginosa 1 ml, then the rats were injected on the wounded back respectively with dMSCs modified by hBD 2 (n=10), or pure dMSCs (n=10) or none as control (n=10). The repair effect was evaluated by observing the amount of bacteria under the scar, wound healing time and the percentage of remaining wound area. Results The amount of bacteria under the scar in rats that were transplanted with dMSCs modified by hBD 2 was less than that in rats transplanted with dMSCs or controls (P
