The Correlation Between Aquaporin-4 Expression Around Hematoma and Blood-Brain Barrier Permeability after Intracerebral Hemorrhage in Rats
- VernacularTitle:大鼠脑出血后血肿周围组织水通道蛋白-4表达与血脑屏障通透性的相关性
- Author:
Jianping WANG
;
Jia LIU
- Publication Type:Journal Article
- Keywords:
aquaporin-4;
intracerebral hemorrhage;
blood-brain barrier;
rat
- From:
International Journal of Cerebrovascular Diseases
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives: To study the correlation between the dynamic expression of aquaporin-4 (AQP-4) around hematoma and the blood-brain barrier permeability after intracerebral hemorrhage in rats. Methods: Forty-two Sprague-Dawley rats were randomly allocated into sham-operation group, and groups of 6 hours, 12 hours, 1, 3, 7 and 14 days (n=6 in each group) after intracerebral hemorrhage. The intracerebral hemorrhage model in rats was established by injecting autologous arterial blood into caudate nucleus. Immunohistochemical method and Evans blue method were used respectively to detect the dynamic changes of AQP-4 around hematoma and the blood-brain barrier permeability in different time periods after intracerebral hemorrhage in rats. Results: (1) The expression of AQP-4 around hematoma increased gradually 12 hours after intracerebral hemorrhage, it increased significantly at day 1 and reached a maximum at day 3. It was slightly higher than normal level at day 7 and almost returned to normal at day 14 (P
