Effects of psychological stress on the function of dopamine receptor in rat:the effect of intervention with tyrosine
- VernacularTitle:心理应激对大鼠多巴胺受体功能的影响及酪氨酸的干预作用
- Author:
Jiaqing HU
;
Ming YIN
;
Jiancheng ZHANG
- Publication Type:Journal Article
- Keywords:
stress, psychological;
receptors, dopamine;
maximal bonding capacity;
balance dissociation constant;
tyrosine
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of psychological stress on the function of dopamine receptor in the central nervous system in rats and the intervention effect of tyrosine. Methods Rats were continuously subjected to psychological stress by communication box model 30min a day for 14 days. They were fed with tyrosine 250mg/kg, 500mg/kg, or 1000mg/kg, respectively. The maximal bonding capacity (Bmax) and the balance dissociation constant (Kd) of D1, D2 receptor of DA at the site of ventral tegmental area (VTA), nucleus accumbens (Nac), mesoprefrontal cortex (mPFC) were determined by radioactive ligand bonding analysis. Results Bmax of the D1 receptors declined significantly in mPFC and Nac area of psychological stress treated group compared with that of control group (P
