Metalloproteinases and disintergrins of snake venom:structures and functions
- VernacularTitle:蛇毒金属蛋白酶及去整合素的结构与功能
- Author:
Donglin JIANG
- Publication Type:Journal Article
- Keywords:
snake venom;
metalloproteinases;
disintegrins
- From:
Academic Journal of Second Military Medical University
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Snake venom metalloproteinase is one of the main function proteins in snake venom.It directly affects the interactions between capillary endothelium cells and basement membrane in local tissues.Snake venom disintegrin and metalloproteinase are derived from the same pre-pro-metalloproteinase,which contains 4 common structural domains: Pre-domain,Pro-domain,Proteinase domains,and Spacer region.Disintegrin,a low molecular weight protein containing several Cys residues,can block the binding of integrins and their ligands and inhibit adhering reaction(cell to cell and cell to extracellular matrix) mediated by integrin.It also plays a significant role in platelet aggregation,infection,inflammation reaction,tumor metastasis,etc..
