Treatment of soft tissue wound with seawater immersion by administration of levofloxacin-chitosan microsphere at early stage
- VernacularTitle:左氧氟沙星壳聚糖微球对兔海水浸泡创伤的早期治疗作用
- Author:
Hongliang SHEN
;
Qiang WANG
;
Fang QIAN
- Publication Type:Journal Article
- Keywords:
wounds and injuries;
seawater;
ofloxacin;
chitosan
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of levofloxacin-chitosan microsphere administrated in early stage seawater immersed wound of soft tissue. Methods A rabbit model of seawater immersed wound of soft tissue was reproduced. Among the control group (n=8) and the group locally treated with levofloxacin powder (n=8) or levofloxacin-chitosan microsphere (n=8), the bacteria number in the wound, the serum endotoxin level, the content of tumor necrosis factor-alpha(TNF-?) in the wound and the serum were assayed before and 6, 12, 24, 48, 72h after seawater immersion. In the latter 2 groups, levofloxaxin concentration in plasma and wound was compared 6, 12, 24, 48, 72h after seawater immersion. Results The bacteria number of the wound in the microsphere group and levofloxacin powder group was lower than that in the control group since 6h after seawater immersion(P
