Long term effect of exendin-4 on body weight reduction in rats
- VernacularTitle:高血糖素样肽-1受体激动剂长期减肥效果研究
- Author:
Qingchun LIU
;
Liwu LIANG
;
Ning GONG
;
Jinzan DU
- Publication Type:Journal Article
- Keywords:
Weight reduction;
Exendin-4;
Pharmacodynamic effect
- From:
Parenteral & Enteral Nutrition
1997;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of exendin-4 on weight reduction in normal rats after long-term subcutaneous injection.Methods:40 Wistar rats aged 6-8 weeks were randomly divided into four groups and were injected subcutaneously with 0,1,5,25 ?g/kg exendin-4 for 26 weeks.Body weight,food intake,cholesterol,triglyceride,kidney fat pad weight and diameter of adipocytes were measured.Results:Body weight,kidney fat pad weight and serum tricyleride in 25?g/kg group were significantly lower than that in control group(P
