Expression and significance of ?-catenin and cox-2 in bulge-originated cells from rat hair follicles
- VernacularTitle:?-CATENIN和COX-2在大鼠毛囊隆突区细胞中的表达及意义
- Author:
Yi ZHANG
;
Yun WANG
;
Yijun ZENG
;
Tian YANG
- Publication Type:Journal Article
- Keywords:
?-catenin;
cox-2;
hair follicle;
bulge;
proliferation
- From:Journal of Third Military Medical University
1983;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of ?-catenin and cox-2 in the bulge cells of hair follicle and investigate the relationship of their expression on cell proliferation. Methods The hair follicle was prepared from the resected cheek skin of 20 Wistar rats aged 7 days. The bulge cells were resected from the intact hair follicle and cultured in vitro. Immunocytochemical technique (ICC) was applied to detect ?-catenin and cox-2 expression in bulge cells at culture day 3, 5, 8, 13. Results ?-catenin and cox-2 strongly expressed in bulge cells and the expression correlated with the culture days. ?-catenin appeared in both plasma and nucleus, while cox-2 only in nucleus. Conclusion ?-catenin and cox-2 were correlated with bulge cells proliferation, and cox-2 might be the target gene of ?-catenin signaling pathway in nucleus.
