EFFECTS OF ZINC ON nNOS AND SS POSITIVE NEURONS IN CEREBRAL CORTEX OF RATS AFTER SLEEP DEPRIVATION
- VernacularTitle:锌对睡眠剥夺大鼠大脑皮层nNOS及SS阳性神经元的影响
- Author:
Jisheng LI
;
Jun CHEN
;
Huaren WANG
;
Heng ZHANG
- Publication Type:Journal Article
- Keywords:
zinc;
sleep deprivation;
neuronal nitric oxide synthase;
somatostatin
- From:
Acta Nutrimenta Sinica
1956;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the effects of zinc (Zn) on neuronal nitric oxide synathase (nNOS) and somatostatin(SS) in cerebral cortex of rats after sleep deprivation (SD), and discuss the protective mechanism of Zn on learning and memory. Method: SD was induced in male Wistar rats by employing “flower pot” technique. The rats in SD+Zn groups were supplemented with Zn in feed (containing 200 mg Zn/kg)for 3 d before SD. The number of nNOS and SS positive neurons in cortex of rats after different time of SD and Zn supplementation were observed. Results: nNOS and SS positive neurons in cortex significantly decreased in SD1 d+Zn group than in SD1d group(P0.05). Conclusion: Zinc can improve the ability of learning and memory of rats after sleep deprivation by protecting nNOS and SS positive neurons in cerebral cortex.
