An analysis for the relationship between Leptin and the nutrition status in peritoneal dialysis patients
- VernacularTitle:腹膜透析患者瘦素水平与营养状况的关系
- Author:
Jinquan WU
;
Zaisheng ZHOU
;
Zhixian PAN
;
Haizhu LI
- Publication Type:Journal Article
- Keywords:
Peritoneal dialysis;
Leptin;
Inflammation;
Nutrition
- From:
Chinese Journal of Primary Medicine and Pharmacy
2005;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship of serum leptin and inflammation with nutrition status in continuous ambulatory peritoneal dialysis(CAPD) patients.Methods 30 CAPD patients and 30 healthy controls were enrolled in the study.Leptin was measured by ELISA,inflammatory factors C reactive protein(CRP),IL-6,TNF-?.These patients were classified to three nutritional categories based on SGA normalnutrition,mild-to-moderate malnutrition,and severe malnutrition.Results CAPD group had significantly higher serum leptin,peritoneal dialysis fluid leptin,insulin,CRP,IL-6 and TNF-?,lower serum Alb than the control group.IL-6 was significantly positive correlation with TNF-?.Serum leptin was no correlation with Alb,CRP,IL-6 and TNF-?.Conclusion Serum leptin and inflammation are closely related to the occurrence of malnutrition in CAPD.
