Expression of transforming growth factor ? and its receptors in hepatocellular carcinoma
- VernacularTitle:转化生长因子?及其受体在肝癌中的表达研究
- Author:
Yan YAN
;
Xuemei ZHANG
;
Li YING
;
Zhaohui WANG
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocellular;
Transforming growth factor ?;
Receptor
- From:
Chinese Journal of Primary Medicine and Pharmacy
2005;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mechanism of transforming growth factor ?(TGF-?) and its receptor in the pathogenesis of hepatocellular carcinoma and to explore its clinical significance.Methods 36 hepatocellular carcinoma tisssues and 36 corresponding cancer-adjacent normal tissues were investigated by immunohistochemistry for the expression of TGF-? and its receptor.Results The expression of TGF-? was distributed mainly in cytoplasm,while its receptor mainly in cellular membrane and cytoplasm.The expression of TGF-? in hepatocellular carcinoma was higher than that of normal tissues(P
