Clinical Significance on the Expression of Estrogen and Progeste rone Receptors in Endometrial Carcinoma,Atypical Hyperplasia and Normal Endome trium.
- VernacularTitle:雌孕激素受体在子宫内膜癌、子宫内膜不典型增生及正常子宫内膜中不同表达的临床意义
- Author:
Jianqing QIN
;
Yili SONG
;
Mingxun LI
- Publication Type:Journal Article
- Keywords:
Endometrial carcinoma;
Atypical;
H yperplasia;
Normal;
Endometrium;
Estrogen receptor;
Progesteron receptor;
Imnuno histochemistry
- From:
Journal of Medical Research
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The purpose of this article is to d iscuss the meaning and the method of testing the ER/PR.We use the anti-ER、 ant i-PR monoclonal antibody SP method to detect the ER/PR in 26 cases of the endome trial cancinoma endometrium、23 cases of the atypical hyperplasia and 22 cases o f the normal endometrium respectively.The result shows that the SP method to t est the ER/PR has different result in carcinoma、atypical hyperplasia and normal endometrium.The expression of ER/PR in carcinoma is distinctly lower than th at in the atypical hyperplasia and normal endometrium.There is no significant d ifferent between the atypical hyperplasia and normal endometrium of the expressi on of ER/PR.However,there are significant different in the ER.PR expressions b e tween normal endometrium and endometrial careinoma,and between atypical hyperpla sia and endometrial careinoma,reflecfing the special biological action of the tu mor.SP method to test the expression of ER/PR has some special meaning to estim ate the prognosis and supervises the treatment of the carcinoma of the uterine.
